%0 Journal Article
%T A Mouse Model of Diet-Induced Obesity Resembling Most Features of Human Metabolic Syndrome
%A Dario C. Ramirez
%A Lucas D. Santillan
%A Marcos D. Mu£¿oz
%A Maria C. Della Vedova
%A Maria G. Plateo-Pignatari
%A Maria J. German¨®
%A Mart¨ªn E. Rinaldi Tosi
%A Miguel W. Fornes
%A Nidia N. Gomez
%A Sandra E. Gomez Mejiba
%A Silvina Garcia
%J Archive of "Nutrition and Metabolic Insights".
%D 2016
%R 10.4137/NMI.S32907
%X Increased chicken-derived fat and fructose consumption in the human diet is paralleled by an increasing prevalence of obesity and metabolic syndrome (MS). Herein, we aimed at developing and characterizing a mouse model of diet-induced obesity (DIO) resembling most of the key features of the human MS. To accomplish this, we fed male C57BL/6J mice for 4, 8, 12, and 16 weeks with either a low-fat diet (LFD) or a high-chicken-fat diet (HFD) and tap water with or without 10% fructose (F). This experimental design resulted in the following four experimental groups: LFD, LFD + F, HFD, and HFD + F. Over the feeding period, and on a weekly basis, the HFD + F group had more caloric intake and gained more weight than the other experimental groups. Compared to the other groups, and at the end of the feeding period, the HFD + F group had a higher adipogenic index, total cholesterol, low-density lipoprotein cholesterol, fasting basal glycemia, insulin resistance, hypertension, and atherogenic index and showed steatohepatitis and systemic oxidative stress/inflammation. A mouse model of DIO that will allow us to study the effect of MS in different organs and systems has been developed and characterized
%K mouse model
%K diet-induced obesity
%K metabolic syndrome
%K adiposity
%K redox change
%K inflammation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140012/