%0 Journal Article
%T CUL4B promotes prostate cancer progression by forming positive feedback loop with SOX4
%A Bo Han
%A Hui Zhang
%A Jing Hu
%A Mei Qi
%A Meng Jiao
%A Peng Su
%A Ruixi Qin
%A Tingting Feng
%A Xinjun Li
%A Xinyi Chen
%A Yan Wang
%A Yanyi Cui
%A Yaoqin Gong
%A Yu Pang
%J Archive of "Oncogenesis".
%D 2019
%R 10.1038/s41389-019-0131-5
%X a, b The expression of CUL4B in PCa tissues compared with normal prostate samples in {"type":"entrez-geo","attrs":{"text":"GSE6956","term_id":"6956"}}GSE6956 (a) and {"type":"entrez-geo","attrs":{"text":"GSE68545","term_id":"68545"}}GSE68545 (b) dataset. c The expression of CUL4B in primary and metastatic PCa tissues compared with the matched normal prostate samples in {"type":"entrez-geo","attrs":{"text":"GSE35988","term_id":"35988"}}GSE35988 dataset. d每g Analysis of CUL4B expression in TCGA dataset. d CUL4B levels in PCa subgroups with different TNM stages; e CUL4B levels in PCa subgroups with different Gleason scores; f the correlation between CUL4B expression and biochemical recurrence-free survival (Pˋ=ˋ0.015, Log-rank test) and g clinical recurrence survival (Pˋ=ˋ0.01, Log-rank test) in the TCGA cohort. h Kaplan每Meier survival analysis of microarray data from 94 PCa cases stratified by high and low CUL4B expression levels (Pˋ=ˋ0.02, Log-rank test). i每k Analysis of CUL4B expression in Qilu cohort by IHC assay. i Representative IHC images of CUL4B expression of benign prostate tissue and PCa tissue with different Gleason score in Qilu cohort. j Kaplan每Meier survival analysis of PCa cases from Qilu cohort according to high and low CUL4B expression levels (Pˋ=ˋ0.17, Log-rank test). k Kaplan每Meier survival analysis of PCa cases with Pre PSA level 4每10ˋng/ml in Qilu cohort stratified by CUL4B levels (Pˋ=ˋ0.01, Log-rank test). *Pˋ<ˋ0.05, **Pˋ<ˋ0.01, ***Pˋ<ˋ0.001. PCa prostate cancer, TCGA The Cancer Genome Atlas, IHC immunohistochemistr
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418142/