%0 Journal Article
%T The Effect of Strain Hardening on the Dynamic Response of Human Artery Segments
%A Antonios E. Giannakopoulos
%A Haralambia P. Charalambous
%A Panayiotis C. Roussis
%J Archive of "The Open Biomedical Engineering Journal".
%D 2017
%R 10.2174/1874120701711010085
%X When subjected to time-dependent blood pressure, human arteries undergo large deformations, exhibiting mainly nonlinear hyperelastic type of response. The mechanical response of arteries depends on the health of tissues that comprise the artery walls. Typically, healthy arteries exhibit convex strain hardening under tensile loads, atherosclerotic parts exhibit stiffer response, and aneurysmatic parts exhibit softening response. In reality, arterial dynamics is the dynamics of a propagating pulse, originating in heart ventricle, propagating along aorta, bifurcating, etc. Artery as a whole cannot be simulated as a lump ring, however its cross section can be simulated as a vibrating ring having a phase lag with respect to the other sections, creating a running pressure wave. A full mathematical model would require fluid-solid interaction modeling continuity of blood flow in a compliant vessel and a momentum equation. On the other hand, laboratory testing often uses small-length arteries, the response of which is covered by the present work. In this way, material properties that change along the artery length can be investigated
%K Hyperelastic arterial model
%K Human artery segments
%K Strain hardening
%K Dynamic analysis
%K Energy density
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748871/