%0 Journal Article
%T Inflammatory-induced spinal dorsal horn neurons hyperexcitability is mediated by P2X4 receptors
%A Franck Aby
%A Lauriane Ulmann
%A Marc Landry
%A Pascal Fossat
%A Sara Whitestone
%J Archive of "Pain Reports".
%D 2018
%R 10.1097/PR9.0000000000000660
%X Purinergic ionotropic P2X receptors (P2RX) are involved in normal and pathological pain transmission. Among them, P2X4 are expressed in dorsal root ganglion and in the spinal cord. Their activation during nerve injury or chronic peripheral inflammation modifies pain sensitivity that leads to the phenomenon of allodynia and hyperalgesia
%K P2X4 Receptor
%K Inflammation
%K Dorsal horn neurons
%K Excitability
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999414/