%0 Journal Article
%T Therapeutic Potential of Prodrugs Towards Targeted Drug Delivery
%A Abhinav P. Mishra
%A Ashish Srivastava
%A Gaurav Tiwari
%A Ruchi Tiwari
%A Suresh Chandra
%J Archive of "The Open Medicinal Chemistry Journal".
%D 2018
%R 10.2174/1874104501812010111
%X In designing of Prodrugs, targeting can be achieved in two ways: site-specified drug delivery and site-specific drug bioactivation. Prodrugs can be designed to target specific enzymes or carriers by considering enzyme-substrate specificity or carrier-substrate specificity in order to overcome various undesirable drug properties. There are certain techniques which are used for tumor targeting such as Antibody Directed Enzyme Prodrug Therapy [ADEPT] Gene-Directed Enzyme Prodrug Therapy [GDEPT], Virus Directed Enzyme Prodrug Therapy [VDEPT] and Gene Prodrug Activation Therapy [GPAT]. Our review focuses on the Prodrugs used in site-specific drug delivery system specially on tumor targeting
%K Prodrug
%K Xenobiotics
%K Cytotoxic
%K ADEPT
%K GDEPT
%K GPAT
%K VDEPT
%K NTR
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210501/