%0 Journal Article
%T Synthesis, Characterization, Antimicrobial and Antioxidant Activities of The Homocyclotrimer Of 4-Oxo-4h-Thieno[3,4-C]Chromene-3-Diazonium Sulfate
%A Chouna Jean Rodolphe
%A Djeukoua Dimo Kamal Sorel
%A Emmanuel Sopbue Fondjo
%A Kouamo Sylvian
%A Kuiate Jules-Roger
%A Ngongang Ndjintchui Arnaud
%A Ngouanet Doriane
%A Nkeng-Efouet-Alango Pepin
%A Sondengam Beibam Lucas
%A Tamokou Jean-de-Dieu
%A Tsemeugne Joseph
%J Archive of "The Open Medicinal Chemistry Journal".
%D 2016
%R 10.2174/1874104501610010021
%X The in situ formed 4-oxo-4H-thieno[3,4-c]chromene-3-diazonium sulfate (5) in the coupling reactions involving the parent 2-aminothiophene (4) and various phenolic and arylamines¡¯ couplers, readily undergoes homocyclotrimerization at low temperature to afford in fairly good yield the first ever reported eighteen member ring heteroaromatic holigomer 6. Compound 6 was fully characterized by its elemental analysis, IR, UV-Vis, 1H-NMR, 13C-NMR and HRMS spectral data. The HMBC and HSQC techniques were used to ascertain the structural assignments. A comparative study on the antimicrobial and antioxidant activities of compounds 3, 4 and 6 was carried out to assess the SAR due to the transformations (from 3 to 6 via 4) on the tested compounds. It was found that compounds 6 and 4 were respectively the most active compounds against bacteria (MIC = 32-64 ¦Ìg/ml) and yeasts (MIC = 16¨C64 ¦Ìg/ml). Compound 6 also showed high radical-scavenging activities and ferric reducing power when compared with vitamin C and BHT used as reference antioxidants
%K 2-aminothiophene
%K Azo compounds
%K Antimicrobial
%K Antioxidant
%K Coumarin
%K Homocyclotrimerization
%K Holigomer
%K SAR
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994106/