%0 Journal Article
%T Estrogen-related receptor ¦Â (ERR¦Â) ¨C renaissance receptor or receptor renaissance?
%A Aileen Fernandez
%A Deanna M. Tiek
%A Rebecca B. Riggins
%A Shailaja D. Divekar
%J Archive of "Nuclear Receptor Signaling".
%D 2016
%R 10.1621/nrs.14002
%X Estrogen-related receptors (ERRs) are founding members of the orphan nuclear receptor (ONR) subgroup of the nuclear receptor superfamily. Twenty-seven years of study have yet to identify cognate ligands for the ERRs, though they have firmly placed ERR¦Á and ERR¦Ã at the intersection of cellular metabolism and oncogenesis. The pace of discovery for novel functions of ERR¦Â, however, has until recently been somewhat slower than that of its family members. ERR¦Â has also been largely ignored in summaries and perspectives of the ONR literature. Here, we provide an overview of established and emerging knowledge of ERR¦Â in mouse, man, and other species, highlighting unique aspects of ERR¦Â biology that set it apart from the other two estrogen-related receptors, with a focus on the impact of alternative splicing on the structure and function of this receptor
%K ESRRB
%K ERRbeta
%K ERR¦Â
%K NR3B2
%K alternative splicing
%K orphan nuclear receptor
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978380/