%0 Journal Article
%T Cystatin C Induces Insulin Resistance in Hippocampal Neurons and Promotes Cognitive Dysfunction in Rodents
%A Cheng Sun
%A Chengfeng Jiang
%A Hao Cai
%A Jinyu Ma
%A Lan Luo
%A Yue Li
%A Zongkang Hu
%J Archive of "Neuroscience Bulletin".
%D 2018
%R 10.1007/s12264-018-0226-6
%X Cystatin C impairs insulin signal transduction in the hippocampus and promotes cognitive dysfunction. A The relative mRNA levels of SOCS1 and SOCS3. 18S rRNA was used as a house-keeping gene. B Western blots of the protein levels using the indicated antibodies. C Quantification of immunoblots as shown in B. D Morris water maze analysis showing impaired spatial and learning memory in CysC-treated mice. E CysC administration affects swimming behavior. Values are presented as mean ¡À SEM from two independent experiments (n = 10; *P < 0.05, **P < 0.01 and ***P < 0.001 versus vehicle-treated mice)
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960459/