%0 Journal Article
%T Chronic treatment with dexamethasone alters clock gene expression and melatonin synthesis in rat pineal gland at night
%A Anderson Carlos Mar£¿al
%A Angela Maria Ramos-Lobo
%A Angelo Rafael Carpinelli
%A Carla Roberta de Oliveira Carvalho
%A Daniela Meneses-Santos
%A Daniella do Carmo Buonfiglio
%A Divan¨ªzia do Nascimento Souza
%A Emerson Ticona Fioretto
%A Fabio Bessa Lima
%A Jos¨¦ Cipolla-Neto
%A Rodrigo Antonio Peliciari-Garcia
%A Rog¨¦rio Ant£¿nio Laurato Sertie
%A Sandra Andreotti
%A Solange Castro Afeche
%J Archive of "Nature and Science of Sleep".
%D 2018
%R 10.2147/NSS.S158602
%X Melatonin is a neuroendocrine hormone that regulates many functions involving energy metabolism and behavior in mammals throughout the light/dark cycle. It is considered an output signal of the central circadian clock, located in the suprachiasmatic nucleus of the hypothalamus. Melatonin synthesis can be influenced by other hormones, such as insulin and glucocorticoids in pathological conditions or during stress. Furthermore, glucocorticoids appear to modulate circadian clock genes in peripheral tissues and are associated with the onset of metabolic diseases. In the pineal gland, the modulation of melatonin synthesis by clock genes has already been demonstrated. However, few studies have shown the effects of glucocorticoids on clock genes expression in the pineal gland
%K clock genes
%K glucocorticoids
%K pineal gland
%K nocturnal insulinemia
%K glycemia profile
%K AANAT activity
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054274/