%0 Journal Article
%T The MicroRNA miR-155 Is Essential in Fibrosis
%A Carol M. Artlett
%A Mousa G. Eissa
%J Archive of "Non-Coding RNA".
%D 2019
%R 10.3390/ncrna5010023
%X The function of microRNAs (miRNAs) during fibrosis and the downstream regulation of gene expression by these miRNAs have become of great biological interest. miR-155 is consistently upregulated in fibrotic disorders, and its ablation downregulates collagen synthesis. Studies demonstrate the integral role of miR-155 in fibrosis, as it mediates TGF-¦Â1 signaling to drive collagen synthesis. In this review, we summarize recent findings on the association between miR-155 and fibrotic disorders. We discuss the cross-signaling between macrophages and fibroblasts that orchestrates the upregulation of collagen synthesis mediated by miR-155. As miR-155 is involved in the activation of the innate and adaptive immune systems, specific targeting of miR-155 in pathologic cells that make excessive collagen could be a viable option before the depletion of miR-155 becomes an attractive antifibrotic approach
%K miR-155
%K fibrosis
%K inflammasome
%K fibroblasts
%K TGF-¦Â1
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468348/