%0 Journal Article
%T Altered neurogenesis in mouse models of Alzheimer disease
%A Oliver Wirths
%J Archive of "Neurogenesis".
%D 2017
%R 10.1080/23262133.2017.1327002
%X Amyloid-¦Â (A¦Â) peptides, as well as a variety of other protein fragments, are derived from proteolytical cleavage of the amyloid precursor protein (APP) and have been demonstrated to play a key role in the pathological changes underlying Alzheimer disease (AD). In AD mouse models, altered neurogenesis has been repeatedly reported to be associated with further AD-typical pathological hallmarks such as extracellular plaque deposition, behavioral deficits or neuroinflammation. While a toxic role of A¦Â in neurodegeneration and impaired neuronal progenitor proliferation is likely and well-accepted, recent findings also suggest an important influence of APP-derived proteolitical fragments like the APP intracellular domain (AICD), as well as of APP itself
%K Alzheimer
%K amyloid precursor protein
%K neurogenesis
%K proliferation
%K transgenic mice
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856097/