%0 Journal Article
%T Successful application of prime and pull strategy for a therapeutic HSV vaccine
%A Akiko Iwasaki
%A David A. Dixon
%A David I. Bernstein
%A Derek A. Pullum
%A Fernando J. Bravo
%A Harvey M. Friedman
%A Peiwen Lu
%A Rhonda D. Cardin
%A Sita Awasthi
%J Archive of "NPJ Vaccines".
%D 2019
%R 10.1038/s41541-019-0129-1
%X Recurrent Lesion Scores. In study 1, HSV-2 infected animals were either vaccinated with trivalent vaccine, treated Ivag/topical with imiquimod, both or neither as described in the methods. Animals were then followed daily for recurrent lesions from day 15¨C70. a shows the cumulative recurrent lesion scores over the time period of day 15¨C70. b shows the total recurrent lesion score from the day after the first immunization (day 15) until day 70. c shows total recurrent lesion score from the day after the third immunization (day 43) until day 70. The numbers above the bars are the number of animals with recurrent lesion/total number of animals ap£¿<£¿0.05 vs PBS; bp£¿<£¿0.001 vs vaccine alone group cP£¿<£¿0.001 vs. PBS and P£¿<£¿0.01 vs the vaccine alone group comparing mean lesion score
%K Preclinical research
%K Experimental models of disease
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671986/