%0 Journal Article
%T Innovations in biomedical nanoengineering: nanowell array biosensor
%A Hak Soo Choi
%A HeaYeon Lee
%A Jonghan Kim
%A JuKyung Lee
%A Sunil Jeong
%A YoungTae Seo
%J Archive of "Nano Convergence".
%D 2018
%R 10.1186/s40580-018-0141-6
%X a Schematic diagram of the ONW array geometry on a gold electrode designed to minimize the unwanted, nonspecific binding or aggregation of biomaterials. b A well-oriented nanowell (ONW) array electrode composed of eight Au pads. The Au electrode on each pad was covered with a resist layer, i.e., a blocking layer. c An AFM image of an ONW array with a 200£¿¡Á£¿200 probe grid on a gold electrode 800 ¦Ìm in diameter. In fabricating the ONW array electrode, a 100£¿¡Á£¿100 nm2 well was generated on the resist surface at 500 nm intervals using nanofabrication technology. d An AFM image of probe ssDNA immobilized by streptavidin-biotin on an ONW array. Although there are also bright spots on the resist layer, these DNA/streptavidin complexes do not contribute to the electrochemical signal
%K Nanobiosensor
%K Electrochemical sensor
%K Nanowell array electrode (NWA)
%K Nanofabrication
%K Immunosensor
%K Electrochemical impedance spectroscopy (EIS)
%K Biomedical nanoengineering systems
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897454/