%0 Journal Article
%T LONG-NONCODING RNAs in gastroesophageal cancers
%A Basudev Chowdhury
%A Fotios Loupakis
%A Giuseppe Nicol¨° Fanelli
%A Hubert Pakula
%A Irene Coati
%A Juozas Kupcinskas
%A Matteo Fassan
%A Nicola Valeri
%A Pierluigi Gasparini
%A Ri Cui
%A Rocco Cappellesso
%J Archive of "Non-coding RNA Research".
%D 2018
%R 10.1016/j.ncrna.2018.10.001
%X Despite continuing improvements in multimodal therapies, gastro-esophageal malignances remain widely prevalent in the population and is characterized by poor overall and disease-free survival rates. Due to the lack of understanding about the pathogenesis and absence of reliable markers, gastro-esophageal cancers are associated with delayed diagnosis. The increasing understanding about cancer's molecular landscape in the recent years, offers the possibility of identifying ¡®targetable¡¯ molecular events and in particular facilitates novel treatment strategies and development of biomarkers for early stage diagnosis. At least 98% of our genome is actively transcribed into non-coding RNAs encompassing long non-coding RNAs (lncRNAs) constituted of transcripts longer than 200 nucleotides with no protein-coding capacity. Many studies have demonstrated that lncRNAs are functional genomic elements playing pivotal roles in main oncogenic processes. LncRNA can act at multiple levels developing a complex molecular network that can modulate directly or indirectly the expression of genes involved in tumorigenesis. In this review, we focus on lncRNAs as emerging players in gastro-esophageal carcinogenesis and critically assess their potential as reliable noninvasive biomarkers and in next generation targeted therapies
%K Gastric cancer
%K Esophageal cancer
%K Long noncoding RNAs
%K Biomarkers
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257886/