%0 Journal Article
%T Correction to: Rp58 and p27kip1 coordinate cell cycle exit and neuronal migration within the embryonic mouse cerebral cortex
%A Isabel Anne Hemming
%A Ivan Enghian Gladwyn-Ng
%A Julian Ik-Tsen Heng
%A Michael Piper
%A Olivier Cl¨¦ment
%A Shan Shan Li
%A Zhengdong Qu
%J Archive of "Neural Development".
%D 2018
%R 10.1186/s13064-017-0098-x
%X p27kip1 restores the defective cell proliferation and radial migration of Rp58 siRNA-treated cortical progenitors. Knockdown of Rp58 leads to a significant reduction in the expression of the cell proliferation marker Ki67. a¨Cd The defective expression of Ki67 in Rp58 siRNA-treated cells could be restored with p27kip1, but not p27kip1(ck-) which is incapable of signalling cell cycle exit owing to a mutation which impairs its cyclin kinase function (e) (F3,8£¿=£¿73, p£¿<£¿0.001, One-way ANOVA, >700 cells counted from 3 independent brains per condition). Similar effects on the co-detection of pHH3, a marker of cell mitosis, were observed (f¨Ck, F2,8£¿=£¿20, p£¿=£¿0.004, One-way ANOVA, >700 cells counted from 3 independent brains per condition). l In addition, suppression of Rp58 by siRNA treatment impaired the migration of GFP-labelled cells, while treatment with either p27kip1 or p27kip1(ck-) promoted the radial migration of Rp58-siRNA treated cells from the VZ/SVZ to the IZ (F2,8£¿=£¿12, p£¿<£¿0.0001, One-way ANOVA, >550 cells counted from 3 independent brains per condition). Scale bar represents 50 ¦Ì
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764026/