%0 Journal Article
%T The phosphatase PPM1A inhibits triple negative breast cancer growth by blocking cell cycle progression
%A Abhijit Mazumdar
%A Gordon B. Mills
%A Graham Poage
%A Jamal Hill
%A Lakshmi Reddy Bollu
%A Powel H. Brown
%A William M. Tahaney
%A Yun Zhang
%J Archive of "NPJ Breast Cancer".
%D 2019
%R 10.1038/s41523-019-0118-6
%X PPM1A is underexpressed in ER-negative breast cancer and correlates with poor survival. a PPM1A is underexpressed in ER-negative breast cancer compared to ER-positive breast cancer in eight publically available datasets. Center lines show median, whiskers represent 95% confidence intervals, and dashes indicate maximum and minimum values. p-values were calculated using Student¡¯s t-test (****p£¿<£¿0.0001). b Low PPM1A expression correlates with poor survival. Kaplan¨CMeier curves were generated from the van de Vijver dataset, showing overall survival of all breast cancer (n£¿=£¿295), ER-positive (n£¿=£¿266), and ER-negative (n£¿=£¿69) patients. High and low expression groups were dichotomized by median PPM1A expression in each group. Curve comparisons of stratified groups were calculated using the Mantel-Cox log-rank test, with p£¿<£¿0.05 being considered statistically significan
%K Breast cancer
%K Predictive markers
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659706/