%0 Journal Article
%T Proteasome-targeted nanobodies alleviate pathology and functional decline in an ¦Á-synuclein-based Parkinson¡¯s disease model
%A Anne Messer
%A Christopher M. Dobson
%A David Butler
%A Diptaman Chatterjee
%A Erwin De Genst
%A Jeffrey H. Kordower
%A Mansi Bhatt
%J Archive of "NPJ Parkinson's Disease".
%D 2018
%R 10.1038/s41531-018-0062-4
%X Experimental design and study overview. a Study design: genes expressing intrabodies or saline vehicle were delivered by viral vector into animals previously lesioned with an ¦Á-syn overexpression vector for observation of treatment effects on behavior and post-mortem analysis of pathology. b Model overview of ¦Á-syn overexpression via viral vector delivery of human ¦Á-syn into the substantia nigra pars compacta (scale bar: B¡ª50¦Ìm). c Schematic of ¦Á-syn protein and target regions for nanobody aptamers VH14*PEST and NbSyn87*PEST. d Diagram of the process of ¦Á-syn fibril formation, sites of intrabody binding, and intrabody-mediated protein clearance mechanism
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105584/