%0 Journal Article
%T Vasodilator-stimulated phosphoprotein promotes liver metastasis of gastrointestinal cancer by activating a ¦Â1-integrin-FAK-YAP1/TAZ signaling pathway
%A Daniel D. Billadeau
%A Hongbin Zhang
%A Jinhua Piao
%A Jinping Lai
%A Lei Wang
%A Ningling Kang
%A Raul Urrutia
%A Rui Kuang
%A Selvaraj Muthusamy
%A Shengbing Huang
%A Wei Zhang
%A Xiaoyu Xiang
%A Yibin Deng
%A Yuanguo Wang
%J Archive of "NPJ Precision Oncology".
%D 2018
%R 10.1038/s41698-017-0045-7
%X High VASP levels correlate with liver metastasis and reduced patient survival. a VASP IHC scores were signed for 63 CRCs of patients. b Representative IHC and H & E images of a CRC show that VASP immunoreactivity markedly enhanced in CRC cells as compared to the benign colonic tissues. Bar, 100£¿¦Ìm. c VASP IHC data of 27 patients with paired primary CRCs and liver biopsies are shown. In CRCs with high levels of VASP, 14 out of 18 cases (78.8%) had metastases in the liver. In CRCs with low levels of VASP, 0 out of 9 cases (0%) had metastases in the liver. P£¿=£¿0.0002 by Fisher¡¯s exact test. d Distribution of VASP IHC scores of 53 PDACs of patients is shown. e Representative VASP IHC and H & E images of a PDAC show that VASP immunoreactivity markedly increased in PDAC cells (arrow) as compared to epithelial cells of a benign duct (arrowhead). Bar, 100£¿¦Ìm. f, g Kaplan¨CMeier survival analysis revealed that high expression levels of VASP correlated with reduced overall and disease-free survival of PDAC patients. P£¿<£¿0.05 by Log-rank test, n is shown in the graph
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871906/