%0 Journal Article
%T Rehabilitative exercise and spatially patterned nanofibrillar scaffolds enhance vascularization and innervation following volumetric muscle loss
%A Adam Davies
%A Cynthia Alcazar
%A Guang Yang
%A Karina H. Nakayama
%A Linda Doan
%A Marco Quarta
%A Ngan F. Huang
%A Patrick Paine
%A Thomas A. Rando
%J Archive of "NPJ Regenerative Medicine".
%D 2018
%R 10.1038/s41536-018-0054-3
%X Characterization of aligned nanofibrillar collagen scaffold aggregates. a Schematic diagram of three-dimensional randomly oriented scaffold bundle and scanning electron microscopy (SEM) image of nanofibril organization. b Schematic diagram of three-dimensional parallel-aligned scaffold bundle and SEM image of nanofibril organization. c, d Mechanical characterization of stiffness by Young¡¯s Modulus c and maximum load d between randomly oriented scaffolds (random) and aligned scaffolds (n£¿=£¿5). e Cellular attachment of human endothelial cells to aligned nanofibrillar scaffolds. Scale bars: 400£¿¦Ìm a, b, 50£¿¦Ìm e. Arrow denotes the direction of nanofibril alignment. Statistically significant comparisons: * P£¿<£¿0.05, ***P£¿<£¿0.001. Error bars denote standard deviatio
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141593/