%0 Journal Article %T Preclinical Safety Evaluation of Ophthalmic Viscosurgical Devices in Rabbits and a Novel Mini-Pig Model %A Arlene E. Gwon %A Brad Gray %A Ling C. Huang %A Lisa J. Kloft %A Ronika S. Leang %J Archive of "Ophthalmology and Therapy". %D 2019 %R 10.1007/s40123-019-0167-9 %X Rabbit pyrogenicity study conducted on HEALON5 PRO OVD demonstrates HEALON OVD products are non-pyrogenic. Three separate studies were conducted on three different lots of HEALON5 PRO OVD. Each study was conducted with n£¿=£¿4, one control ¡°C¡± and three experimental animals (£¿ 1, £¿ 2, £¿ 3). Temperatures were taken every 30 min for a total of 3 h. Bars from left to right in each grouping are baseline, 1 h, 1.5 h, 2 h, 2.5 h, and 3 h. Data from all three studies are graphed togethe %K Cataract surgery %K Endothelial cell %K HEALON OVD %K HEALON PRO OVD %K Ophthalmic viscosurgical device %K Sodium hyaluronate %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393256/