%0 Journal Article %T Left Atrial Appendage Closure Device With Delivery System: A Health Technology Assessment %A Health Quality Ontario %J Archive of "Ontario Health Technology Assessment Series". %D 2017 %X Atrial fibrillation is a common cardiac arrhythmia, and 15% to 20% of those who have experienced stroke have atrial fibrillation. Treatment options to prevent stroke in people with atrial fibrillation include pharmacological agents such as novel oral anticoagulants or nonpharmacological devices such as the left atrial appendage closure device with delivery system (LAAC device). The objectives of this health technology assessment were to assess the clinical effectiveness and cost-effectiveness of the LAAC device versus novel oral anticoagulants in patients without contraindications to oral anticoagulants and versus antiplatelet agents in patients with contraindications to oral anticoagulants %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515321/