%0 Journal Article
%T A cautionary note on the selectivity of oncolytic poxviruses
%A Bingtao Tang
%A David L Bartlett
%A Edward J Roy
%A Grant McFadden
%A Jia Liu
%A Joanna L Shisler
%A Zong Sheng Guo
%J Archive of "Oncolytic Virotherapy".
%D 2019
%R 10.2147/OV.S189832
%X Oncolytic viruses selectively infect cancer cells while avoiding infection of normal cells. Usually, selectivity is demonstrated by injecting a virus into tumor-bearing mice and observing infection and lysis of tumor cells without infection of other tissues. The general view is that this selectivity is due to tropisms of the virus. However, apparent selectivity could be due to accessibility. For example, intravenously injected virus may not gain access to cells within the central nervous system (CNS) because of the blood¨Cbrain barrier
%K oncolytic virus
%K central nervous system toxicity
%K glioma
%K safety
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375109/