%0 Journal Article
%T Investigating the Conformation of S100¦Â Protein Under Physiological Parameters Using Computational Modeling: A Clue for Rational Drug Design
%A Elvis K. Tiburu
%A Gordon Awandare
%A Ibrahim Issah
%A Mabel Darko
%A Nadia K. Amoateng
%A Robert E. Armah-Sekum
%A Samuel K. Kwofie
%A Stephen O. A. Gyampo
%J Archive of "The Open Biomedical Engineering Journal".
%D 2018
%R 10.2174/1874120701812010036
%X Physiochemical factors such as temperature, pH and cofactors are well known parameters that confer conformational changes in a protein structure. With S100¦Â protein being a metal binding brain-specific receptor for both extracellular and intracellular functions, a change in conformation due to the above-mentioned factors, can compromise their cellular functions and therefore result in several pathological conditions such as Alzheimer¡¯s disease, Ischemic stroke, as well as Myocardial Infarction
%K S100¦Â Protein
%K Molecular Dynamics
%K Cofactors
%K Energy Minimization
%K Physiological Parameters
%K Alzheimer's
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048829/