%0 Journal Article
%T Bone Defect Regeneration by a Combination of a ¦Â-Tricalcium Phosphate Scaffold and Bone Marrow Stromal Cells in a Non-Human Primate Model
%A Atsushi Okawa
%A Ichiro Torigoe
%A Kenichi Shinomiya
%A Masato Yuasa
%A Sadao Morita
%A Shinichi Sotome
%A Takashi Taniyama
%A Tomokazu Masaoka
%A Toshitaka Yoshii
%A Tsuyoshi Yamada
%J Archive of "The Open Biomedical Engineering Journal".
%D 2016
%R 10.2174/1874120701610010002
%X Reconstruction of large bone defects is a great challenge in orthopedic research. In the present study, we prepared composites of bone marrow-derived stromal cells (BMSCs) and ¦Â-tricalcium phosphate (¦Â-TCP) with three novel aspects: proliferation of BMSCs with continuous dexamethasone treatment, cell loading under low pressure, and use of autologous plasma as the cell loading medium. The effectiveness of the resulting composite for large bone-defect reconstruction was tested in a non-human primate model, and the bone union capability of the regenerated bones was examined
%K Bone marrow-derived stromal cells
%K bone regeneration
%K long bone defect
%K non-human primate
%K tissue engineering
%K ¦Â-tricalcium phosphate.
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800777/