%0 Journal Article
%T Herpes simplex virus keratouveitis recurrence following intravitreal bevacizumab injection
%A Ashok Sharma
%A Chintan Singh
%A Mohit Dogra
%A Ramandeep Singh
%A Simar Rajan Singh
%J Archive of "Oman Journal of Ophthalmology".
%D 2019
%R 10.4103/ojo.OJO_147_2016
%X We report a case of recurrence of herpes simplex virus (HSV) keratouveitis following the intravitreal injection of bevacizumab for macular edema secondary to central retinal vein occlusion (CRVO) in a previously adequately treated patient of herpetic keratouveitis. A 47-year-old man with the previous history of HSV keratouveitis was administered 2 doses of intravitreal bevacizumab in the right eye for CRVO, at an interval of 4 weeks. Following the second dose, the patient developed decreased vision, corneal edema, and anterior segment inflammation. Since he was a previously known case of HSV keratouveitis with a positive polymerase chain reaction for HSV from the aqueous, oral valacyclovir was started along with topical steroids and cycloplegics. He showed a good response to treatment with resolution of keratouveitis. This case demonstrates that the recurrence of herpetic keratouveitis can be a possible complication of intravitreal bevacizumab, which may occur even after prior uneventful injections
%K Bevacizumab
%K central retinal vein occlusion
%K herpes simplex virus
%K keratouveitis
%K recurrence
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380159/