%0 Journal Article
%T Role of Cancer Stem Cell, Apoptotic Factor, DNA Repair, and Telomerase Toward Radiation Therapy Response in Stage IIIB Cervical Cancer
%A Andrijono Andrijono
%A Bethy Suryawathy Hernowo
%A Dwi Anita Suryandari
%A Lisnawati Rachmadi
%A Mpu Kanoko
%A Nurjati Chairani Siregar
%A Saptawati Bardosono
%A Sri Mutya Sekarutami
%J Archive of "Oman Medical Journal".
%D 2019
%R 10.5001/omj.2019.43
%X Cancer stem cells are involved in radioresistant cancers. Transcription factors Sry-related HMG box (SOX2) and octamer binding transcription factor 4 (OCT4) can confer pluripotent cell characteristics and self-renewal ability and are involved in carcinogenesis, metastasis, tumor recurrence, and resistance to therapy. Apoptosis, DNA repair, and telomerase factors also contribute to radioresistance. We sought to identify the role of SOX2 and OCT4 as cancer stem cell markers and their effects on apoptosis (via caspase 3), DNA repair (Chk1) and telomerase (hTERT) in conferring resistance to radiotherapy
%K Cancer Stem Cells
%K Cervical Cancer
%K Oct-4 Transcription Factor
%K Radiation Tolerance
%K SOXB1 Transcription Factors
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505348/