%0 Journal Article
%T Germline genetic testing in prostate cancer ¨C further enrichment in variant histologies?
%A Emmanuel S. Antonarakis
%A Mark C. Markowski
%J Archive of "Oncoscience".
%D 2018
%R 10.18632/oncoscience.403
%X The genetics and heritability of prostate cancer have been well studied and continue to be elucidated. Recently, germline mutations in homologous recombination (HR) DNA repair genes have been observed in a significant proportion of men with prostate cancer. Based on the pioneering work in breast and ovarian cancers, pharmacological targeting of the poly-ADP ribose polymerase (PARP) enzyme has been shown to induce synthetic lethality in HR-deficient tumors. The discovery and characterization of germline HR mutations in prostate cancer patients may increase therapeutic options and lead to improved clinical outcomes
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978447/