%0 Journal Article
%T Diagnosis of an indistinct Leydig cell tumor by positron emission tomography-computed tomography
%A Byung Seok Lee
%A Jinkyoung Kong
%A Joo Hyun Park
%A SiHyun Cho
%A Yoo Mee Park
%A Young Sik Choi
%J Archive of "Obstetrics & Gynecology Science".
%D 2019
%R 10.5468/ogs.2019.62.3.194
%X A 51-year-old perimenopausal female patient presented with hirsutism and voice thickening which was started approximately one and a half years ago. Her initial hormone assay revealed elevated plasma testosterone, 5a-dihydrotestosterone, and dehydroepiandrosterone (DHEA) levels and therefore androgen-secreting tumor was first suspected. However, the lesion was inconspicuous on transvaginal sonography, abdominal-pelvic computed tomography (CT) scan, and pelvic magnetic resonance (MRI) imaging. Consequently, 18F-fluorodeoxyglucose (FDG) positron emission tomography-CT was performed, which localized the lesion as a focal FDG uptake within the right adnexa. Total laparoscopic hysterectomy with bilateral salpingo-oophorectomy was performed, and although visible gross mass lesions were not observed intraoperatively, pure Leydig cell tumor was pathologically confirmed within the right ovary. Plasma testosterone, 5a-dihydrotestosterone, and DHEA levels were normalized postoperatively. Clinical signs of virilization were also significantly resolved after 3-months of follow-up
%K Sertoli-Leydig cell tumor
%K PET-CT
%K Diagnosis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520550/