%0 Journal Article
%T Pediatric Multiple Endocrine Neoplasia Type 2B: Clinicopathological Correlation of Perilimbal Mucosal Neuromas and Treatment of Secondary Open-Angle Glaucoma
%A Carol L. Karp
%A Kara M. Cavuoto
%A Kingsley C. Okafor
%A Sander R. Dubovy
%A Ta Chen Chang
%J Archive of "Ocular Oncology and Pathology".
%D 2018
%R 10.1159/000484053
%X Ocular findings of multiple endocrine neoplasia type 2B (MEN 2B) include prominent corneal nerves, mucosal neuromas of the conjunctiva, glaucoma, and dry eyes. A 15-year-old girl with MEN 2B presents with advanced secondary open-angle glaucoma and bilateral perilimbal masses. High-resolution optical coherence tomography (HR-OCT) of the perilimbal lesions showed normal epithelial thickness and subepithelial lobular areas of mixed reflectivity, which correlates well with histopathologic findings of benign mucosal neuromas. The patient underwent bilateral gonioscopy-assisted transluminal trabeculotomy (GATT) in both eyes, which achieved adequate intraocular pressure control at short-term follow-up. To the authors' knowledge, this is the first report correlating HR-OCT and histopathologic findings in benign mucosal neuroma associated with MEN 2B, and the first description of secondary open-angle glaucoma associated with MEN 2B treated with GATT
%K Multiple endocrine neoplasia type 2B
%K Mucosal neuromas
%K Juvenile open-angle glaucoma
%K Anterior segment optical coherence tomography
%K Gonioscopy-assisted transluminal trabeculotomy
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939668/