%0 Journal Article
%T Optimizing Parkinson¡¯s disease diagnosis: the role of a dual nuclear imaging algorithm
%A J. William Langston
%A Jesse C. Wiley
%A Michele Tagliati
%J Archive of "NPJ Parkinson's Disease".
%D 2018
%R 10.1038/s41531-018-0041-9
%X MIBG-DAT dual imaging diagnostic algorithm. MIBG abnormality separates multisystem Lewy body disease (MLBD) pathologies, including idiopathic Parkinson¡¯s disease (PD) and dementia with Lewy bodies (DLB) from other types of parkinsonism. 123I-Ioflupane measures the integrity of nigrostriatal dopamine projections. Low dopamine transporter (DAT) levels in the caudate, putamen or both, in either brain hemisphere, are consistent with a parkinsonian disorder, independently of its nature. In subjects with appropriate symptoms and signs, the combination of the two imaging modalities allows discriminating four distinct pathologies: (1) non-parkinsonian disorders (upper left quadrant, dual test normality); (2) atypical non-Lewy body parkinsonism (upper right quadrant, normal MIBG, and abnormal DAT); (3) early-stage MLBD or pre-symptomatic parkinsonism (lower left quadrant, abnormal MIBG and normal DAT); (4) MLBD, either DLB or PD (lower right quadrant, abnormal MIBG, and DAT
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824845/