%0 Journal Article
%T In IgA Nephropathy, Glomerulosclerosis Is Associated with Increased Urinary CD80 Excretion and Urokinase-Type Plasminogen Activator Receptor-Positive Podocyturia
%A Alejandro Iotti
%A Alexis Muryan
%A Amalia Schiel
%A An¨ªbal Stern
%A Cristian Costales-Collaguazo
%A Elsa Zotta
%A Fernando Lombi
%A Hern¨¢n Trimarchi
%A Jos¨¦ Andrews
%A Mariano Forrester
%A Mat¨ªas Paulero
%A Romina Canzonieri
%A Romina Iriarte
%A Tatiana Rengel
%A Vanesa Pomeranz
%J Archive of "Nephron Extra".
%D 2017
%R 10.1159/000473888
%X Podocyturia may determine the evolution to podocytopenia, glomerulosclerosis, and renal failure. According to the Oxford classification of IgA nephropathy (IgAN), the S1 lesion describes glomerulosclerosis. Urokinase-type plasminogen activator receptor (uPAR) participates in podocyte attachment, while CD80 increases in glomerulosclerosis. We measured uPAR-positive urinary podocytes and urinary CD80 (uCD80) in controls and in IgAN subjects with M1E0S0T0 and M1E0S1T0 Oxford scores to assess a potential association between podocyturia, inflammation, and glomerulosclerosis
%K IgA nephropathy
%K Glomerulonephritis
%K Glomerulosclerosis
%K CD80
%K Urokinase-type plasminogen activator receptor
%K Podocyturia
%K Proteinuria
%K Integrins
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473063/