%0 Journal Article
%T Dysregulation of microRNA metabolism in motor neuron diseases: Novel biomarkers and potential therapeutics
%A Elisa De Paola
%A Maria Paola Paronetto
%A Veronica Verdile
%J Archive of "Non-coding RNA Research".
%D 2019
%R 10.1016/j.ncrna.2018.12.001
%X In the last 15 years, several classes of small regulatory RNAs have been identified, uncovering the widespread impact of non-coding elements in the human genome on cell homeostasis and human diseases. MicroRNAs (miRNAs) are a family of small, non-coding RNAs, which exert silencing of mRNA targets in a sequence-dependent fashion. Many miRNAs are specifically expressed in the central nervous system, where they display roles in differentiation, neuronal survival, neuronal plasticity and learning. On the other hand, deregulated miRNA/mRNA expression networks are deeply involved in neurodegeneration
%K Motor neuron diseases
%K microRNAs
%K RNA therapeutics
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404378/