%0 Journal Article
%T Superhydrophobic lab-on-chip measures secretome protonation state and provides a personalized risk assessment of sporadic tumour
%A A. Castellini
%A A. Donato
%A A. Lavano
%A C. K. Pirrone
%A C. Mignogna
%A C. Voci
%A D. Maisano
%A D. Scumaci
%A E. Di Fabrizio
%A E. Ferraro
%A E. Scali
%A F. Amato
%A F. Casale
%A F. Gentile
%A F. Givigliano
%A G. Cuda
%A G. Donato
%A G. Guzzi
%A G. Perozziello
%A G. Sena
%A G. Volpentesta
%A I. Presta
%A L. Ferrara
%A M. Careri
%A M. Giannetto
%A M. Greco
%A M. L. Coluccio
%A M. Renne
%A N. Copped¨¨
%A N. Innaro
%A N. Malara
%A P. Candeloro
%A R. Majewska
%A R. Sacco
%A S. Bonacci
%A U. Bottoni
%A V. Mollace
%A V. Onesto
%A V. Trunzo
%J Archive of "NPJ Precision Oncology".
%D 2018
%R 10.1038/s41698-018-0069-7
%X Super-hydrophobic chip incorporates five gold electrodes in a line for site-selective measurements of a solution (a). Individual silicon micropillars are modified to incorporate gold nano-electrodes, an intermediate layer of C4F8 and a superficial layer of the conductive PEDOT:PSS polymer, bar in the inset is 5 ¦Ìm (b). Sensors are positioned from the centre (S3) to the border (S1, S5) of the device; the output of each sensor is a function of time I(t) that reaches a constant value in a characteristic time ¦Ó; the intensity of I is proportional to the externally applied voltage V (c). Convenient post-processing of a sample enables super-hydrophobicity with contact angles as large as 165¡ã (d). SEM micrographs of the device magnified at small magnification factors (e). SEM micrograph of the device shows the gold nano-electrodes positioned on the pillar surface for localized sensing (f). Due to super-hydrophobicity, biological solutions can be manipulated and connected to an external gate during operation (g). The images were partially adapted from https://www.nature.com/articles/srep18992 1
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242957/