%0 Journal Article
%T Opposing activities of oncogenic MIR17HG and tumor suppressive MIR100HG clusters and their gene targets regulate replicative senescence in human adult stem cells
%A Aibek Smagul
%A Aikan A. Akanov
%A Aliya Nussupbekova
%A Bryan Krastins
%A I. King Jordan
%A Lu Wang
%A Mary F. Lopez
%A Maryann Vogelsang
%A Meenakshi Gaur
%A Ping Niu
%A Victoria V. Lunyak
%A Yueqiang Zhao
%J Archive of "NPJ Aging and Mechanisms of Disease".
%D 2017
%R 10.1038/s41514-017-0006-y
%X Schematic representation of sample collection for analysis and immunological stability of hADSCs upon replicative SEN. a hADSCs were isolated from healthy donor subcutaneous tissue and passaged ex-vivo as described in materials and methods. Colorimetric detection of SA-¦Â-Gal (10x) in SR and SEN hADSCs is shown. Samples were collected and processed for transcriptomic and proteomic studies as described in material and methods. b The table summarizes immunostability of hADSCs in SR and senescent states, which were assessed by expression of MSC-positive and MSC-negative CD markers, details shown in Supplementary Table S
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460214/