%0 Journal Article
%T Different Fgfs have distinct roles in regulating neurogenesis after spinal cord injury in zebrafish
%A Ashley L. Siegel
%A Jan Kaslin
%A Jean Kitty K. Y. Tang
%A Patricia R. Jusuf
%A Peter D. Currie
%A Phong D. Nguyen
%A Yona Goldshmit
%J Archive of "Neural Development".
%D 2018
%R 10.1186/s13064-018-0122-9
%X Fgf signalling increases neurogenesis after spinal cord injury. a Micrographs through intact non-injured adult zebrafish spinal cord show weak p-MAPK expression. b Micrographs through adult zebrafish spinal cord two weeks post injury (wpi) shows p-MAPK levels upregulated particularly in non-radial glia GFAP negative neurons at the central canal at the lesion site (arrows, B) (n£¿=£¿5) some of which are Islet1 positive (c). d, e While Fgf signalling gain (spry4£¿/£¿) or loss (Tg(hsp70l:dn-fgfr1-EGFP) has no effect on NeuN+ neurons in intact spinal cord (SC), two weeks after injury, the significant increase in NeuN+ neurons in WT can be further increase with Fgf signaling gain and abolished with Fgf signaling loss. Graphs shows mean ¡À SEM, (n£¿=£¿6 fish /group) ** p£¿<£¿0.01. Scale bars in A, B and C are 25£¿¦Ìm, scale bar in D is 50 ¦Ì
%K Motor neuron
%K Fgf2
%K Fgf3
%K Fgf8
%K Neural regeneration
%K Islet 1
%K C-met
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240426/