%0 Journal Article %T Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging %A Beatrix Grubeck-Loebenstein %A Giuseppe Del Giudice %A Jeffrey J. Stoddard %A J£¿rg J. Goronzy %A Paul-Henri Lambert %A T. Mark Doherty %A Tomas Mrkvan %J Archive of "NPJ Aging and Mechanisms of Disease". %D 2018 %R 10.1038/s41514-017-0020-0 %X Factors influencing immunosenescence. Aging is influenced by multifaceted extrinsic and intrinsic factors leading to a progressive impairment of the function of various organs and systems, including the immune responsiveness, leading to increased susceptibility to infectious diseases and to reduced response to vaccinatio %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740164/