%0 Journal Article
%T Caveolin-1 as a pathophysiological factor and target in psoriasis
%A Ilja L. Kruglikov
%A Philipp E. Scherer
%J Archive of "NPJ Aging and Mechanisms of Disease".
%D 2019
%R 10.1038/s41514-019-0034-x
%X Spatiotemporal interaction of the skin and underlying dermal WAT (dWAT) in psoriasis: a normal non-psoriatic skin; b modification of the dWAT located beneath the future psoriatic lesion leading to a stable local reduction of Cav-1 content in this tissue and inflammation in this area (Cav-1 expression in the covering skin is normal); c to compensate this Cav-1 reduction in dWAT, exosomes start to transport Cav-1 from the skin to dWAT which appears as a sink for Cav-1; d this exosomal transport (outflow) is not able to compensate for the strong deficiency of Cav-1 in dWAT; instead, it causes continuous reduction of Cav-1 in the skin and, consequently, its inflammatory state and hyperproliferatio
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363785/