%0 Journal Article
%T Bioavailability of Orally Delivered Alpha-Tocopherol by Poly(Lactic-Co-Glycolic) Acid (PLGA) Nanoparticles and Chitosan Covered PLGA Nanoparticles in F344 Rats
%A Cristina Sabliov
%A Lacey C. Simon
%A Rhett W. Stout
%J Archive of "Nanobiomedicine".
%D 2016
%R 10.5772/63305
%X It is hypothesized that the bioavailability of ¦ÁT (alpha-tocopherol), an antioxidant, can be improved when delivered by poly(lactic-co-glycolic) acid (PLGA) nanoparticles (NPs) and chitosan covered PLGA nanoparticles (PLGA-Chi NPs), and that the mucoadhesive properties of chitosan may enhance absorption of ¦ÁT. PLGA and PLGA-Chi NPs were characterized by measuring entrapment efficiency, size, polydispersity, and zeta potential. Nanoparticle physical stability, chemical stability of entrapped ¦ÁT, and release kinetics were also measured. Pharmacokinetic studies were conducted by administering PLGA (¦ÁT) NPs, PLGA-Chi (¦ÁT) NPs, and free ¦ÁT via oral gavage in rats. The size and zeta potential of the two particle systems were 97.87 ¡À 2.63 nm and £¿36.2 ¡À 1.31 mV for PLGA(¦ÁT) NPs, and 134 ¡À 2.05 nm and 38.0 ¡À 2.90 mV for PLGA-Chi (¦ÁT) nanoparticles in DI water. The particle systems showed to be stable during various in vitro assays. Bioavailability of nanodelivered ¦ÁT was improved compared to the free ¦ÁT, by 170% and 121% for PLGA and PLGA-Chi NPs, respectively. It was concluded that while chitosan did not further improved bioavailability of ¦ÁT, PLGA NPs protected the entrapped drug from the GI environment degradation and proved to be an effective delivery system for ¦ÁT
%K Alpha-tocopherol
%K Bioavailability
%K PLGA
%K Chitosan
%K Nanodelivery
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998269/