%0 Journal Article
%T pAKT pathway activation is associated with PIK3CA mutations and good prognosis in luminal breast cancer in contrast to p-mTOR pathway activation
%A Amir Sonnenblick
%A Christos Sotiriou
%A David Venet
%A Noam Pond¨¦
%A Sylvain Broh¨¦e
%J Archive of "NPJ Breast Cancer".
%D 2019
%R 10.1038/s41523-019-0102-1
%X pAKT and p-mTOR signatures derived from the TCGA. a Venn diagram shows no intersection between the pAKT and p-mTOR gene signatures. b Network representation of the gene signatures. Each node represents the genes up-regulated or down-regulated in the signature. Edges show signatures sharing a significant number of genes. Network clustering shows the tendency of these signatures to cluster together according to their proliferation status. c Integrated analysis of the PIK3CA/pAKT/m-TOR pathway in the TCGA. Luminal breast cancer subtypes differ by pAKT and p-mTOR activity. The panel includes a protein-based (RPPA) proteomic status. Tumors were ordered first by mRNA subtype (luminal A versus B). P values were calculated using the Mann¨CWhitney tes
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355773/