%0 Journal Article
%T SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes
%A Chisato Inoue
%A Chong Zhao
%A Lixiang Wang
%A Masatoshi Nomura
%A Miyako Udono
%A Yoshinori Katakura
%A Yumi Tsuduki
%J Archive of "NPJ Aging and Mechanisms of Disease".
%D 2017
%R 10.1038/s41514-017-0011-1
%X Functional analysis of SMARCD1 role in cellular senescence. Relative gene expression of SMARCD1 in presenescnet and senescent TIG-1 cells (a), in scramble shRNA (scr-shRNA)-transduced and SMARCD1-silenced presenescent TIG-1 cells (b), and in mock-transduced and SMARCD1-overexpressing senescent TIG-1 cells (F). (c) Expression of SMARCD1 in scr-shRNA-transduced and SMARCD1-silenced presenescent TIG-1 cells. (d) Proliferation rate of scr-shRNA-transduced (¡ð) and SMARCD1-silenced presenescent TIG-1 (¡ñ, shSMARCD1-1; ¡ö, shSMARCD1-2). Cellular senescence phenotypes, quantitatively analyzed by IN Cell analyzer 1000. Activity and expression of senescence markers were measured in scr-shRNA-transduced and SMARCD1-silenced presenescent TIG-1 cells (e), and in mock-transduced and SMARCD1-overexpressing senescent TIG-1 cells (h). (g) Proliferation rate of mock- (¡ð) and SMARCD1-transduced TIG-1 cells (¡ñ). Data were analyzed by two-sided Student¡¯s t-test and expressed as mean£¿¡À£¿SD. P£¿<£¿0.05 was considered significant (* P£¿<£¿0.05; ** P£¿<£¿0.01; *** P£¿<£¿0.001
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577293/