%0 Journal Article
%T Neuroprotective role of retinal SIRT3 against acute photo-stress
%A Eriko Toda
%A Hideto Osada
%A Jonathan B. Lin
%A Kazuo Tsubota
%A Kenya Yuki
%A Mitsuhiro Watanabe
%A Norimitsu Ban
%A Rajendra S. Apte
%A Shunsuke Kubota
%A Yoko Ozawa
%J Archive of "NPJ Aging and Mechanisms of Disease".
%D 2017
%R 10.1038/s41514-017-0017-8
%X Retinal SIRT3 was mainly expressed in mitochondria, and the level was decreased with age. a, b In situ hybridization of Sirt3 in the retina of 10-week-old C57BL6/J mice. Scale bars: a 20£¿¦Ìm b 200£¿¦Ìm. GCL ganglion cell layer, IPL inner plexiform layer, INL inner nuclear layer, OPL outer plexiform layer, ONL outer nuclear layer, OS outer segment, RPE retinal pigment epithelium, AS antisense, S sense. c Representative Immunoblot of SIRT3 for subcellular fraction of the retina of 10-week-old C57BL6/J mice. T total retina, C cytoplasmic, M mitochondrial, N nuclear, CM cytoplasmic and mitochondrial fractions. d¨Cg Immunoblot of young (10 weeks old) and old (60 weeks old) C57BL6/J mice retina against nicotinamide phosphoribosyltransferase (NAMPT) e, SIRT1 f, and SIRT3 g (n£¿=£¿5 for each group). *p£¿<£¿0.05 by two-tailed unpaired t-test. Values are mean£¿¡À£¿S
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712523/