%0 Journal Article
%T RegenDbase: a comparative database of noncoding RNA regulation of tissue regeneration circuits across multiple taxa
%A Ashley M. Smith
%A Benjamin L. King
%A Christina A. Dykeman
%A Grace A. Smith
%A Michael C. Rosenstein
%A Viravuth P. Yin
%J Archive of "NPJ Regenerative Medicine".
%D 2018
%R 10.1038/s41536-018-0049-0
%X RegenDbase provides fundamental analyses of regeneration circuits within individual experiments and comparative analyses across experiments and species. a Organizational workflow for multi-layered data processing and analysis of published (public) and unpublished (internal) gene expression datasets. b Examples of how RegenDbase was used to compare: (i) genes common or unique to two pairwise contrasts of early stages of zebrafish heart regeneration (0 vs. 1£¿dpa and 0 vs. 3£¿dpa); (ii) genes common or unique to contrasts from early stages of zebrafish caudal fin regeneration (0 vs. 4£¿dpa) and zebrafish heart regeneration (0 vs. 3£¿dpa); (iii) comparative analyses of early zebrafish heart (0 vs. 3£¿dpa) and neonatal mouse heart (0 vs. 1£¿dpa) regeneration showing the number of orthologs commonly differentially expressed along with the number of zebrafish and mouse genes unique to each model. c Heatmap representing genes from precomputed pairwise contrasts from a subset of significantly up- and downregulated transcripts between uninjured and 3 days post-amputation (dpa) regenerating adult ventricles. The temporal expression profile for cxcr4b, an essential regeneration gene, is shown as a boxplot in the web interfac
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973935/