%0 Journal Article
%T Identification of a novel potassium channel (GiK) as a potential drug target in Giardia lamblia: Computational descriptions of binding sites
%A Araceli Castillo-Romero
%A Claudia Lisette Charles-NiŁżo
%A Filiberto Guti¨¦rrez-Guti¨¦rrez
%A Lissethe Palomo-Ligas
%A Rafael Cort¨¦s-Z¨˘rate
%A Ver¨®nica Yadira Ochoa-Maganda
%J Archive of "PeerJ".
%D 2019
%R 10.7717/peerj.6430
%X The protozoan Giardia lamblia is the causal agent of giardiasis, one of the main diarrheal infections worldwide. Drug resistance to common antigiardial agents and incidence of treatment failures have increased in recent years. Therefore, the search for new molecular targets for drugs against Giardia infection is essential. In protozoa, ionic channels have roles in their life cycle, growth, and stress response. Thus, they are promising targets for drug design. The strategy of ligand-protein docking has demonstrated a great potential in the discovery of new targets and structure-based drug design studies
%K Giardia lamblia
%K Potassium channel
%K Potential target
%K Molecular modeling
%K Docking
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397635/