%0 Journal Article
%T DNA methylation at the mu-1 opioid receptor gene (OPRM1) promoter predicts preoperative, acute, and chronic postsurgical pain after spine fusion
%A Bobbie L Stubbeman
%A Hong Ji
%A Kristie Geisler
%A Lili Ding
%A Lisa J Martin
%A Matthew T Weirauch
%A Senthilkumar Sadhasivam
%A Vidya Chidambaran
%A Xue Zhang
%J Archive of "Pharmacogenomics and Personalized Medicine".
%D 2017
%R 10.2147/PGPM.S132691
%X The perioperative pain experience shows great interindividual variability and is difficult to predict. The mu-1 opioid receptor gene (OPRM1) is known to play an important role in opioid-pain pathways. Since deoxyribonucleic acid (DNA) methylation is a potent repressor of gene expression, DNA methylation was evaluated at the OPRM1 promoter, as a predictor of preoperative, acute, and chronic postsurgical pain (CPSP)
%K OPRM1
%K epigenetics
%K pain
%K chronic postsurgical pain
%K DNA methylation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432115/