%0 Journal Article
%T Pharmacodynamic genetic polymorphisms affect adverse drug reactions of haloperidol in patients with alcohol-use disorder
%A Alexander Olegovich Kibitov
%A Dmitry Alekseevich Sychev
%A Dmitry Vladimirovich Ivashchenko
%A Elena Anatolievna Grishina
%A Evgeny Alekseevich Bryun
%A Kristina Anatolievna Ryzhikova
%A Ludmila Mikhaylovna Savchenko
%A Mikhail Sergeevich Zastrozhin
%A Vadim Markovich Brodyansky
%A Valentin Yurievich Skryabin
%J Archive of "Pharmacogenomics and Personalized Medicine".
%D 2017
%R 10.2147/PGPM.S140700
%X Antipsychotic action of haloperidol is due to blockade of D2 receptors in the mesolimbic dopamine pathway, while the adverse drug reactions are associated with striatal D2 receptor blockade. Contradictory data concerning the effects of genetic polymorphisms of genes encoding these receptors and associated structures (catechol-O-methyltransferase [COMT], glycine transporter and gene encoding the density of D2 receptors on the neuronal membrane) are described
%K haloperidol
%K pharmacogenetics
%K DRD2
%K COMT
%K DAT
%K alcohol addiction
%K alcohol-use disorder
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511016/