%0 Journal Article
%T Capsaicin reverses the inhibitory effect of licochalcone A/¦Â-Arbutin on tyrosinase expression in b16 mouse melanoma cells
%A Bai-Chao An
%A Bin Zhang
%A Hong-Xia Zhu
%A Huo-Ji Chen
%A Jun-Hui Hong
%A Li-Dong Weng
%A Qiang Liu
%A Shi-Fa Ruan
%A Shi-Jian Xiang
%A Si-Wei Cao
%J Archive of "Pharmacognosy Magazine".
%D 2018
%R 10.4103/pm.pm_103_17
%X Melanin is synthesized by melanocytes, which are located in the basal layer of the skin. After synthesis, melanin is further deposited on the surface of the skin to form black spots or chloasma. Tyrosinase is a rate-limiting enzyme that plays an important role in melanogenesis. Currently, there are many drugs that inhibit tyrosinase expression to further reduce melanogenesis. Nevertheless, some of these could reverse the pharmacological effect of other drugs, when used simultaneously
%K Capsaicin
%K licochalcone A
%K melanin
%K melanocyte
%K tyrosinase
%K ¦Â-arbutin
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858230/