%0 Journal Article
%T Developmental programming of obesity by maternal exposure to concentrated ambient PM2.5 is maternally transmitted into the third generation in a mouse model
%A Bin Pan
%A Haidong Kan
%A Ji Zhou
%A Minjie Chen
%A Shimin Tao
%A Wanjun Wang
%A Weihua Li
%A Xiaoyun Xie
%A Xingke Huang
%A Yanyi Xu
%A Zhekang Ying
%A Zhouzhou Li
%J Archive of "Particle and Fibre Toxicology".
%D 2019
%R 10.1186/s12989-019-0312-6
%X Maternal pre-conception exposure to CAP is sufficient to decrease offspring¡¯s birth weight and increase adulthood adiposity. a Exposure scheme: E, start of exposure; P, presence of sperm plug; L1, birth of litter one; L2, birth of litter two; L3, birth of litter three. b. The birth weight of male F1 offspring. n£¿=£¿20¨C33/group. c The birth weight of female F1 offspring. n£¿=£¿9¨C35/group. d The growth trajectory of male F1 offspring. e The growth trajectory of female F1 offspring. f and g. The representative histological (H&E staining) images (f) and adipocyte size (g) of male F1 offspring¡¯s perigonadal adipose tissues obtained using ImageJ. h and i. The representative histological (H&E staining) images (h) and adipocyte size (I) of female F1 offspring¡¯s perigonadal adipose tissues obtained using ImageJ. n£¿=£¿12¨C30/group, *p£¿<£¿0.05 versus FA, one-way or two-way ANOV
%K PM2.5
%K Maternal exposure
%K Obesity
%K Developmental programming
%K Cross-generational transmission
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604135/