%0 Journal Article
%T Quantitative biokinetics over a 28£¿day period of freshly generated, pristine, 20 nm titanium dioxide nanoparticle aerosols in healthy adult rats after a single two-hour inhalation exposure
%A Alexander Wenk
%A Carsten Schleh
%A Manuela Semmler-Behnke
%A Martin Sch£¿ffler
%A Nadine Haberl
%A Neil Gibson
%A Stephanie Hirn
%A Uwe Holzwarth
%A Wolfgang G. Kreyling
%J Archive of "Particle and Fibre Toxicology".
%D 2019
%R 10.1186/s12989-019-0303-7
%X The online version of this article (10.1186/s12989-019-0303-7) contains supplementary material, which is available to authorized users
%K Spark ignition generated titanium dioxide nanoparticle aerosols
%K Characterization of physicochemical particle properties
%K Intratracheal inhalation of freshly generated aerosols
%K Translocation across air-blood-barrier
%K Accumulation in secondary organs and tissues
%K Long-term alveolar macrophage-mediated nanoparticle clearance
%K Nanoparticle relocation into the interstitium
%K Re-entrainment from interstitium back to lung epithelium for clearance towards the larynx
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617842/