%0 Journal Article
%T PIPAC EstoK 01: Pressurized IntraPeritoneal Aerosol Chemotherapy with cisplatin and doxorubicin (PIPAC C/D) in gastric peritoneal metastasis: a randomized and multicenter phase II study
%A Clarisse Eveno
%A Ingrid Jouvin
%A Marc Pocard
%J Archive of "Pleura and Peritoneum".
%D 2018
%R 10.1515/pp-2018-0116
%X Peritoneal metastasis (PM) from gastric cancer often remains undiagnosed until it reaches an advanced stage. Despite curative management combining perioperative systemic chemotherapy, cytoreductive surgery (CRS), and hyperthermic intraperitoneal chemotherapy (HIPEC), treated patients¡¯ 5 year survival rate remains under 20£¿% when patients are carefully selected. Palliative intravenous chemotherapy in patients with non-resectable cancer is frequently associated with poor long-term benefit and an estimated survival time below 1 year. Recently, two retrospectives studies reported that Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) improves patients¡¯ overall survival without impairing their quality of life (QoL). This promising result needs however to be studied on large randomized clinical trial to validate the effect of PIPAC on survival and QoL of patients with gastric PM
%K gastric adenocarcinoma
%K peritoneal carcinomatosis
%K Pressurized IntraPeritoneal Aerosol Chemotherapy
%K doxorubicin
%K cisplatin.
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405009/