%0 Journal Article
%T Pharmaceutical inhibition of mTOR in the common marmoset: effect of rapamycin on regulators of proteostasis in a non-human primate
%A Adam B. Salmon
%A Corinna Ross
%A Matthew Lelegren
%A Suzette Tardif
%A Yuhong Liu
%J Archive of "Pathobiology of Aging & Age Related Diseases".
%D 2016
%R 10.3402/pba.v6.31793
%X Inhibition of mechanistic target of rapamycin (mTOR) has emerged as a viable means to lengthen lifespan and healthspan in mice, although it is still unclear whether these benefits will extend to other mammalian species. We previously reported results from a pilot experiment wherein common marmosets (Callithrix jacchus) were treated orally with rapamycin to reduce mTOR signaling in vivo in line with previous reports in mice and humans. Further, long-term treatment did not significantly alter body weight, daily activity, blood lipid concentrations, or glucose metabolism in this cohort
%K healthspan
%K protein chaperone
%K proteasome
%K immunoproteasome
%K autophagy
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920937/